Yes. I think they have some sort of "Front Page" options thet make it easier.
I would suggest using only Dreamweaver though... it's HTML is much cleaner.
It's just like with any other server. you setup your remote server info in Dreamweaver, and click upload. you will have a set of files on your HD and the live files will be on the server. after your site is up you only need to update individual flies as needed.
they also have a control panel (cpanelX) which is where you create email accounts, get stats, cron jobs MySQL administration etc.
their forums are good too
www.lunarforums.com
thats where you can get most of your questions answered.
You can create an account on their forum whether you use them or not.
there are many webhost that offer good service, so just look around
I also use GoDaddy for one of my clients... its a dedicated server...$3K per year.